痛泻要方对肝郁脾虚型IBS-D大鼠肠道菌群的影响研究          下载免费PDF全文

张建峰  陈婕  赵双梅 《应用海洋学学报》2020,36(10):154

目的：观察痛泻要方对肝郁脾虚型肠易激综合征（IBS-D）大鼠肠道菌群的影响，基于“脑肠菌轴”角度探讨痛泻要方治疗IBS-D的作用机制。方法：将24只SD大鼠随机分为4组：即空白组（NormalG)、模型组(ModelG)、双歧杆菌三联活菌片组(ShuangG)、痛泻要方组（TongG)，每组各6只。通过夹尾结合番泻叶灌胃的方法制备肝郁脾虚型IBS-D大鼠模型，分别给予相应药物灌胃，NormalG以及ModelG予0.9%氯化钠注射液灌胃。采用16srDNA测序法分析IBS-D大鼠肠道菌群在治疗前后的变化。结果：在门水平上，TongG较ModelG增加了厚壁菌门、拟杆菌门的种群丰度，有效降低了含较多致病菌的变形菌门丰度；在纲水平上，TongG较ModelG增加了梭状芽胞杆菌纲、拟杆菌纲、杆菌纲的丰度，降低了丙型变形菌纲丰度；在目水平上，TongG较ModelG增加了梭菌目、乳杆菌目、拟杆菌目的丰度，降低了黄色单胞菌目、肠杆菌目丰度；在属水平上，TongG较ModelG增加了巨单胞菌属、劳特氏菌属种群丰度，有效降低了寡养单胞菌属丰度；韦恩图和花瓣图显示，NormalG菌群数量最多，ModelG最少，TongG较ModelG增多且程度大于ShuangG，共有种群数量更趋近于NormalG；稀释曲线和等级聚类曲线结果均显示TongG的肠道菌群丰度及均匀度更趋近NormalG；箱型图展示TongG与NormalG多样性、离散程度、中位数更接近；PCOA分析结果显示TongG相较ShuangG，与NormalG重合度更高。结论：痛泻要方能纠正IBS-D患者存在的菌群失衡，促使肠道菌群结构趋于正常，且改善程度优于双歧杆菌三联活菌片。  相似文献   

中国古典叙事文学的时空叙事数字模型研究——以《李娃传》为例     

马昭仪  何捷  刘帅帅 《地球信息科学学报》2020,22(5):967-977

文学制图作为一种再现文学空间的文学地理研究方法,能将历时性叙事与共时性空间进行相互映射,但是过往的实践案例往往受限于单一的研究视角,忽略了二者内部的整体性互动关系及其与外部时空的联系。为了促使文本中的线性叙事与并置空间作为整体概念而服务于当代的文学制图实践活动,本文依据巴赫金文学时空体中的历史时空、文本时空和读者时空的概念提出了一个叙事时空数字模型,并以唐传奇小说《李娃传》为文学制图实践案例,可视化再现了这个以唐长安为中心的爱情故事。在融合了计算叙事和地理叙事研究路径的基础上,本文对叙事文本所蕴含的顺序的、多维的和背景性的信息,进行了语义提取、语义的时空循环映射和“时间—时空—空间”的叙事再现,从而呈现叙事的语言线性、体验性和意义性的特征。该模型以开放的和可对话的框架帮助当代人理解古典文学叙事及其地方性历史语境,同时将拓展从宏观、微观的角度以沉浸式方式对地方（place）进行叙事的潜力。  相似文献   

Impacts of small cascaded hydropower plants on river discharge in a basin in Southern China     

Xu Xiao  Xiaohong Chen  Lilan Zhang  Rouyi Lai  Jie Liu 《水文研究》2019,33(10):1420-1433

The run‐off volume altered by the construction of hydropower plants affects ecohydrological processes in catchments. Although the impacts of large hydropower plants have been well documented in the literature, few studies have been conducted on the impacts of small cascaded hydropower plants (SCHPs). To evaluate the impacts of SCHPs on river flow, we chose a representative basin affected by hydropower projects and, to a lesser degree, by other human activities, that is, the Qiuxiang River basin in Southern China. The observed river discharge and climate data during the period of 1958–2016 were investigated. The datasets were divided into a low‐impact period and a high‐impact period based on the number of SCHPs and the capacities of the reservoirs. The daily river discharge alteration was assessed by applying the Indicators of Hydrologic Alteration. To separate the impact of the SCHPs on the local river discharge from that of climate‐related precipitation, the back‐propagation neural network was used to simulate the monthly average river discharge process. An abnormal result was found: Unlike large reservoirs in large watersheds, the SCHPs regulated the flows during the flood season but were not able to mitigate the droughts during the dry season due to their limited storage and the commonly occurring inappropriate interregulations of the SCHPs. The SCHPs also reduced the annual average river discharge in the research basin. The contribution of the SCHPs to the river discharge changes was 85.37%, much higher than the contributions of climate change (13.43%) and other human activities (1.20%). The results demonstrated that the impacts of the SCHPs were different from those of large dams and reservoirs that regulate floods and relieve droughts. It is necessary to raise the awareness of the impacts of these river barriers.  相似文献   

黔北正安地区五峰组—龙马溪组页岩气地质特征及有利区预测     

贺永忠  向坤鹏  安亚运  易成兴  杨忠琴  于宁 《中国地质调查》2020,7(3):21-29

为明确黔北正安地区上奥陶统五峰组至下志留统龙马溪组的页岩气地质特征,充分应用页岩气地质调查、重磁电、二维地震、地质调查井及测试分析等工作方法,开展黔北正安地区1:5万页岩气基础地质调查,对五峰组至龙马溪组富有机质页岩的分布、沉积环境、有机地球化学、岩石矿物、储集性能及含气性等特征进行分析研究,结果表明: 研究区五峰组—龙马溪组富有机质页岩为深水陆棚相沉积,主要分布有安场向斜、斑竹向斜和泥高向斜,厚度14.5~55 m,埋深0~3 200 m; 有机碳(TOC)含量1.0%~4.0%,有机质镜质体反射率(R_o)为1.82%~2.23%,有机质类型以Ⅰ型干酪根为主; 岩石主要由石英、长石和黏土矿物组成,脆性矿物含量高,一般大于50%; 孔隙度为2.03%~3.89%,渗透率为0.35×10^-5~1.86×10^-5μm²,表现为低孔、特低渗的特征; 最高含气量为2.88 m³/t,显示出较好的含气性特征。综合分析和评价圈出3个页岩气聚集有利区,分别为安场区块、斑竹区块和泥高区块,这为研究区页岩气进一步勘探开发指明了方向。  相似文献   

Analysis of Multiple Tourist Agents’ Symbiotic Relationship on the View of Tourist Enterprises Based on a Grey Correlation Model: A Case Study of Qinghai Lake,China     

XIANG Cheng  TANG Zhongxia  LIU Menglin  SHAO Li 《资源与生态学报(英文版)》2019,10(3):335-344

Tourism symbiosis is a social phenomenon consisting of many complex factors, and the reciprocal cooperation among multiple tourist agents at tourist destinations is the crux of the sustainable development of tourism. This study is from the perspective of tourist enterprises, and introduces the Symbiosis Theory of genecology. A quantitative evaluation is used to analyze both the equilibrium state of the combined symbiotic behavior routes and the behavior patterns of tourist enterprises with local governments, community residents, tourists and tourist enterprises around Qinghai Lake. The findings reveal: (1) the symbiotic behavior routes of the multiple tourist agents “E→G-R-T-E” in the Qinghai Lake area are constituted of intense symbiotic indications, while the maximum dimensionality of symbiotic interest of “E→G-R-T-E” is still in the state of disequilibrium and dissymmetry; (2) the symbiotic model of multiple tourist agents “E→G-R-T-E” in the Qinghai Lake area is an asymmetrically positive symbiotic model. It is proposed that, by establishing symbiotic mechanisms for guidance, decisions, supervisory control and profit distribution, the participation mechanism for multiple agents “E-G-R-T” can be further standardized. Moreover, tourist enterprises should be regarded as the primary agents to optimize the symbiotic model for “E→G-R-T-E” through the reinforcement of integrative supply and the construction of integrative effect, and finally promote the integrative symbiotic model of symmetrical reciprocity of the E-R-G-T model “driven by scenic areas, responsive to community residents, affected by local governments and enjoyed by tourists.”  相似文献   

自由段先注浆对预应力锚索抗拔试验结果影响研究     

杨庆光  柳雄  刘杰  何杰  梁凌川  陈斌 《岩土力学》2020,41(10):3317-3325

为了解决无法采用已注浆锚索进行抗拔试验问题，基于界面脱黏剪切模型，利用荷载传递和弹性变形理论，考虑锚索锚固段与自由段长度比Lb /La的影响，建立了采用自由段已注浆锚索抗拔试验结果评价锚索抗拔性能的方法。结果表明：自由段注浆对锚索抗拔力有较大幅度的提高，尤其是当界面剪切阶段由弹性向脱黏过渡时，提高比例快速增加，并在脱黏后逐渐趋于稳定。其次，锚索自由段与锚固段交界面处剪切位移和轴力最大，并向两端逐渐降低。随着拉拔力的提高，界面剪切位移和轴力都不断增大，同时向锚索两端的衰减速度也加快。此外，弹性阶段时剪应力曲线为山峰型，而脱黏阶段为马鞍型，并随抗拔力的提高，马鞍开口逐渐扩大。最后，锚固段与自由段长度比Lb /La对锚索极限抗拔力的影响较小，其极限抗拔力折减系数?Q取值介于0.81～0.83之间，且Lb /La =2.5时，?Q计算值仅比实测结果小6.02%，验证了本文方法的可行性。  相似文献   

从水文学产汇流角度分析碱坪沟“8·13”泥石流特征     

宋国虎  李强  陈容  王灿  向波 《四川地质学报》2020,40(1):93-97

本研究以四川省都江堰市龙池镇碱坪沟泥石流流域对象,基于HEC-HMS流域分布式水文模型,利用RS和GIS技术提取流域产汇流参数,模拟分析碱坪沟8·13泥石流的暴雨汇流过程,结合流域内土地利用类型分布,模拟降雨-径流关系,并综合考虑泥石流的相关特征参数,利用情景分析法探讨泥石流流域内的土地利用类型变化对泥石流汇流过程的影响关系。  相似文献   

Species Abundance Distribution Patterns of a Toona ciliata Community in Xingdoushan Nature Reserve     

WANG Yang  ZHU Shengjie  LI Jie  HE Xiuling  JIANG Xiongbo  ZHANG Min 《资源与生态学报(英文版)》2019,10(5):494-503

With the goal of model fitting species abundance distribution patterns of the tree, shrub and herb layers of the natural Toona ciliata community in Xingdoushan Nature Reserve, Enshi Autonomous Prefecture, Hubei Province, we used the data collected from the field survey and employed different ecological niche models. The models tested were the broken stick model (BSM), the overlapping niche model (ONM) and the niche preemption model (NPM), as well as three statistic models, the log-series distribution model (LSD), the log-normal distribution model (LND) and the Weibull distribution model (WDM). To determine the fitted model most suitable to each layer, the fitting effects were judged by criteria of the lowest value of Akaike Information Criterion (AIC), Chi-square and the K-S values with no significant difference (P>0.05) between the theoretical predictions and observed species abundance distribution values. The result showed: (1) The fitting suitability and goodness of fit of the tree, shrub and herb layers by using the three ecological niche models were ranked as: NPM>BSM>ONM. Of the three statistical models, by accepting the fitting results of the three layers, WDM was the best fitting model, followed by LND. By rejecting the fitting tests of the herb layer, LSD had the worst fitting effect. The goodness of the statistical models was ranked as: WDM>LND>LSD. In general, the statistical models had better fitting results than the ecological models. (2) T. ciliata was the dominant species of the tree layer. The species richness and diversity of the herb layer were much higher than those of either the tree layer or the shrub layer. The species richness and diversity of the shrub layer were slightly higher than those of the tree layer. The community evenness accorded to the following order: herb>shrub>tree. Considering the fitting results of the different layers, different ecological niche models or statistical models with optimal goodness of fit and ecological significance can be given priority to in studying the species abundance distribution patterns of T. ciliata communities.  相似文献   

以PAC为原料合成锂吸附剂的工艺研究          下载免费PDF全文

张文丁  邓小川  朱朝梁  樊发英  张毅  樊洁  史一飞  卿彬菊 《盐湖研究》2019,27(3)

研究了聚合氯化铝（PAC）为原料合成锂吸附剂的基本工艺路线，并探究了加料方式、反应物配比、反应温度、反应时间和加料速度等对所合成吸附剂吸附量的影响，研究结果表明配比是影响吸附剂吸附量的最主要因素，得到了最佳合成条件，在此条件下所合成吸附剂对锂离子的吸附容量为6.1mg/g。推断吸附剂的主要成分为晶态或非晶态的LiCl·2Al(OH)3·nH2O，同时含有Al(OH)3、(CaO)3Al2O3·6H2O及 LiCl·H2O等成分。从吸附结果来看，结晶度较差的片状LiCl·2Al(OH)3·nH2O和非晶态的Al(OH)3为主成分的吸附剂吸附性能最好。  相似文献   

经济海藻病害及防控技术的研究进展     

杨慧超  李杰  阎永伟  唐磊  茅云翔  莫照兰 《海洋科学》2019,43(1):101-111

经济海藻的病害一直是海藻人工栽培的一大障碍,往往造成严重的经济损失。目前对藻类病害的研究大多集中于病原鉴定,而病原的多样性和复杂的海区微环境增加了病原分离和鉴定的难度。本文综述了经济海藻病害发生的原因、病原的多样性和致病机制、病原的鉴定、检测和防治方法,并对未来我国海藻病害研究方向进行了展望,以期对藻类病害的防控提供参考。  相似文献